Procuring viable tumor for molecular studies may be necessary for diagnostic, therapeutic and prognostic purposes. This is most often required when the neoplasm is a sarcoma. Whether submitting tissue for evaluation of a possible lymphoma or soft tissue sarcoma, the tissue should be sent fresh, without formalin, for an intraoperative consultation to determine if the specimen is adequate (enough viable tumor is present to complete the studies). Surgical closure should occur after the adequacy of the tissue has been assessed and reported to the surgeon. The pathologist can then divide the tumor into the necessary quantities and place it in the appropriate media.
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