Epulis fissuratum is an inflammatory fibrous hyperplasia of oral mucosa caused by frictional irritation due to a denture. The lesion usually occurs in the labial vestibule and appears as folds of redundant mucosa separated by a fissure. The depth of the fissure may be ulcerated. Biopsy reveals hyperplasia of moderately cellular fibrous connective tissue covered by squamous epithelium that ranges from atrophic to hyperplastic with focal ulceration. The inflammatory infiltrate is chronic unless near an ulcer. The lesion offers no diagnostic challenge and is treated by surgical excision and adjustment of the denture to prevent recurrence.
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