Project Title Molecular Events In Oral Cancer Progressionprevention

Principal Investigator & Institution Stoner, Gary D. Professor and Chairman Medicine Administrtation Ohio State University 1960 Kenny Road Columbus, Oh 43210 Timing Fiscal Year 2002 Project Start 15-SEP-1998 Project End 30-JUN-2003 Summary The goals of the Oral Cancer Research Program (OCRPP) at The Ohio State University are to 1) enhance and facilitate investigations of those interactions between human cells of the oral cavity and tobacco by- products that lead to adverse biological...

Project Title Hpv And Mrps In Oral Cancer Pathogenesis

Principal Investigator & Institution Palefsky, Joel M. Professor of Medicine University of California San Francisco 500 Parnassus Ave San Francisco, Ca 941222747 Summary The molecular pathogenesis of oral cancer remains poorly understood. A substantial proportion of oral dysplasias and cancers, but not all, are associated with human papillomavirus (HPV) infection. A better understanding of the mechanisms underlying HPV+ and HPV-oral disease incidence and progression is needed to develop new...

Project Title Chemoprevention Of Oral Cancer With Bbic

Principal Investigator & Institution Meyskens, Frank L. Professor of Medicine Medicine University of California Irvine Irvine, Ca 926977600 Timing Fiscal Year 2003 Project Start 14-MAR-1997 Project End 31-AUG-2008 Summary (provided by applicant) The long term objective of this proposal is to determine whether Bowman-Birk Inhibitor (BBI) Concentrate (C), a protease inhibitor extracted from soybeans, can cause regression of oral leukoplakia and whether certain candidate intermediate marker...

Project Title Etiology And Prevention Of Oral Cancer

Principal Investigator & Institution El-Bayoumy, Karam E. Director of Research Institute for Cancer Prevention 1 Dana Rd Valhalla, Ny 10595 Timing Fiscal Year 2003 Project Start 01-MAY-2003 Project End 30-APR-2008 Summary (provided by applicant) A model of progression of head and neck sqiamous cell carcinoma (HNSCC) in humans has been described which includes up-regulation of cyclin D1, activation of Stat-3, and expression of high levels of cyclooxygenase-2 (COX- 2). Mutations and...

Project Title Contrast Enhanced Spectroscopic Detection Of Oral Cancer

Principal Investigator & Institution Motamedi, Massoud Professor Biomedical Engineering Center University of Texas Medical Br Galveston 301 University Blvd Galveston, Tx 77555 Timing Fiscal Year 2002 Project Start 01-SEP-2001 Project End 31-AUG-2003 Summary (Provided by Applicant) Each year about 31,000 Americans develop oral cancer. Squamous cell carcinoma accounts for 95 percent of all malignant oral lesions Oral squamous cell carcinoma is a condition that will kill approximately half of...

Project Title Characterization Of The 11Q13 Amplicon In Oral Cancer

Principal Investigator & Institution Gollin, Susanne M. Professor Human Genetics University of Pittsburgh at Pittsburgh 350 Thackeray Hall Pittsburgh, Pa 15260 Timing Fiscal Year 2002 Project Start 01-AUG-2002 Project End 31-JUL-2007 Summary (provided by applicant) Gene amplification, the generation of extra copies of a gene(s), is a common and critically important genetic defect in oral cancer (OSCC) cells. Amplification of chromosomal band 11q13, which harbors the cyclin D1 gene (CCND1)...

Project Title Neoadjuvant Therapy Of Or Cancer By Inhibiting Nfkappab

Principal Investigator & Institution Wang, Cun-Yu Associate Professor Biologic & Materials Sciences University of Michigan at Ann Arbor 3003 South State, Room 1040 Ann Arbor, Mi 481091274 Timing Fiscal Year 2002 Project Start 30-SEP-1999 Project End 31-AUG-2004 Summary Oral cancer typically presents as a very malignant tumor. More than 90 percent of oral cancers are squamous cell carcinoma which also is one of the most common malignant types occurring lung, skin, and ovary. At advanced...

Project Title Cadherins In Oral Squamous Cell Carcinomas

Principal Investigator & Institution Johnson, Keith R. Professor Oral Biology University of Nebraska Medical Center Omaha, Ne 681987835 Timing Fiscal Year 2003 Project Start 01-APR-1998 Project End 31-JAN-2008 Summary (provided by applicant) Cadherins are the transmembrane component of the adherence junction, a structure that may appear at first glance to be a static structure. Nevertheless, we know that cells must be able to adjust the strength of cellular adhesions in order to respond to...

The Combined Health Information Database

The Combined Health Information Database summarizes studies across numerous federal agencies. To limit your investigation to research studies and oral cancer, you will need to use the advanced search options. First, go to http chid.nih.gov index.html. From there, select the Detailed Search option (or go directly to that page with the following hyperlink The trick in extracting studies is found in the drop boxes at the bottom of the search page where You may refine your search by. Select the...