Medications Or Substances That May Worsen Obstructive Sleep Apnea Or Its Symptoms See Also Chapter

Effective, nonpharmacologic treatment of OSA, particularly CPAP, has been shown to improve comorbid medical conditions (e.g., heart failure, hypertension) and decrease healthcare resource utilization (11,24). Effective CPAP can also improve the safety of concomitant medication that can worsen OSA such as sedative/hypnotics, anesthetics, analgesics, anticonvulsants, antihistamines, and antipsychotics (25,26). Table 2 lists medications that may be dangerous for individuals with sleep apnea, the mechanism of worsening apnea, and any special considerations for use. Even though CPAP can improve the safety of these concomitant medications, clinician monitoring with polysomnography in a sleep lab may be needed to facilitate

TABLE 2 Medications or Substances That May Worsen Obstructive Sleep Apnea

Medication

Mechanism

Special considerations

Opioids

CNS depression

Safe use with PAP is possible

Sleep Apnea

Sleep Apnea

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