Hypercapnic Central Apnea

Noninvasive positive pressure ventilation (NIPPV) is the therapeutic intervention of choice (see also Chapter 10). Noninvasive ventilation using pressure support mode (bilevel nasal positive pressure) has virtually supplanted volume-preset ventilators. There is evidence that NIPPV exerts a salutary effect on survival in patients with ventilatory failure secondary to amyotrophic lateral sclerosis (56,57). Whether NIPPV exerts a similar effect in conditions associated with nocturnal ventilatory failure has yet to be determined.

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