Continuous Positive Airway Pressure Mode of Action

The concept of CPAP in managing respiratory failure is relatively old (11). However, the original experiments using CPAP in sleep apnea followed from the notion that closure of the oropharynx in OSA results from an imbalance of the forces (12) that normally keep the upper airway open. In the first description of CPAP use for treatment of OSA in 1981 (2), it was suggested that nasal CPAP acts as a pneumatic splint to prevent collapse of the pharyngeal airway, by elevating the pressure in the oropharyngeal airway and reversing the transmural pressure gradient across the pharyngeal airway (Fig. 1). This notion has been subsequently confirmed by a number of studies which either demonstrate the "pneumatic splint" effect by endoscopic or other imaging, or show that CPAP does not increase upper airway muscle activity by reflex mechanisms (13). Detailed magnetic resonance imaging has confirmed that CPAP increases airway volume and airway area, and reduces lateral pharyngeal wall thickness and upper airway edema secondary to chronic vibration and occlusion of the airway (14). The apparatus providing the pressure at the nasal

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

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