Conclusions

Modafinil is the only FDA-approved medication indicated to manage excessive daytime sleepiness in patients with OSA who have only partially responded to CPAP. Each routine medication should be evaluated to determine its impact or lack of impact on an individual patient's breathing during sleep. Agents that may improve OSA include: SSRIs, antihypertensives, and estrogen/progesterone therapy in women. Medications or substances that may worsen sleep apnea include opioids, barbiturates, sedative/hypnotics, and alcohol. CPAP therapy can improve the safety of medications known to worsen sleep apnea. Clinician monitoring with polysom-nography in a sleep laboratory is optimal to facilitate adjustments in CPAP fit and to assess whether the concomitant medication is actually safe when used with CPAP.

Sleep Apnea

Sleep Apnea

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