Although thyroid cancer accounts for less than 1% of all clinical cancers, it is the commonest form of endocrine malignancy and accounts for more deaths than all other endocrine cancers combined, excluding cancers of the reproductive tract. Thyroid neoplasms may arise from either the follicular endothelium or from the C cells (Table 3). The parafollicular C cells give rise to medullary carcinomas. Rarely, the thyroid may be the site of origin of a lymphoma or sarcoma. Primary tumors of kidney, breast, lung and melanomas can metastasize to the thyroid gland.
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