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Figure 3. Normal 111In-leukocyte scan. Note the normal accumulation within bone marrow, liver and spleen. As in this patient, the spleen typically shows the most intense accumulation of 111In-leukocytes.

accumulation in the inflamed mucosa is typically extremely rapid but peristalsis of leukocytes shed into the bowel lumen can lead to distal migration with inaccurate localization unless very early (1 hour) images are obtained. Low grade inflammation may not be apparent on the early images and sensitivity is much better at 24 hours. Occasionally non-inflammatory hyperemia can be misinterpreted as inflammation if only one set of images is acquired. Comparing early and delayed images is particularly helpful in this regard, since true inflammation should show a progressive increase in leukocyte activity.

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