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Figure 6. Eosinphilic granuloma of bone (histiocytosis X). Eosinophilic granulomas are found predominantly in flat bones such as the calvarium, mandible, pelvis and ribs. The radiophosphate bone scan can depict decreased, normal or increased uptake. Patient 1 (left): Posterior view of the skull showing an eosinophilic granuloma characterized by photopenia with a rim of minimal reactive radiophosphate uptake (arrow). Patient 2 (right): Lateral view of the skull demonstrating the "doughnut" sign, i.e., photopenia with a rim of marked reactive radiophosphate accretion.

Figure 6. Eosinphilic granuloma of bone (histiocytosis X). Eosinophilic granulomas are found predominantly in flat bones such as the calvarium, mandible, pelvis and ribs. The radiophosphate bone scan can depict decreased, normal or increased uptake. Patient 1 (left): Posterior view of the skull showing an eosinophilic granuloma characterized by photopenia with a rim of minimal reactive radiophosphate uptake (arrow). Patient 2 (right): Lateral view of the skull demonstrating the "doughnut" sign, i.e., photopenia with a rim of marked reactive radiophosphate accretion.

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