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Figure 4. Soft tissue infection of a left above-knee amputation stump imaged simultaneously with a dual-isotope method. A conventional bone scan with 99mTc-MDP (left) shows normal reaction at the surgical amputation site (arrow). The 111In-leukocyte scan (right) shows focal accumulation more proximally that tracks along the medial femoral cortex (arrowhead).

Figure 4. Soft tissue infection of a left above-knee amputation stump imaged simultaneously with a dual-isotope method. A conventional bone scan with 99mTc-MDP (left) shows normal reaction at the surgical amputation site (arrow). The 111In-leukocyte scan (right) shows focal accumulation more proximally that tracks along the medial femoral cortex (arrowhead).

technetium-99m also leads to greater elution of the label from the WBC and therefore the fractional uptake at 18-24 hours is usually less than with mIn-leukocytes. Nonetheless, in direct comparisons the improved image quality seen with 99mTc-leukocytes offsets any reduced retention such that the two agents are equivalent in terms of their ability to detect inflammatory lesions.

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