Contents

4.1 Overview of Peripheral Neuronal nAChRs

4.1.1 Structure, Composition, and Distribution

4.1.2 Function

4.1.2.1 Automonic Nervous System

4.1.2.2 Sensory Systems

4.2 Methodological Approaches in Neuronal nAChR Research

4.2.1 Classical Pharmacology Studies of Peripheral Neuronal nAChRs

4.2.1.1 Autonomic Nervous System

4.2.1.2 Sensory Systems

4.2.2 Cloning Reveals Multiple Subunits of Neuronal nAChRs

4.2.3 Detection of Nucleic Acids Encoding Neuronal nAChR Subunits

4.2.3.1 Autonomic Nervous System

4.2.3.2 Sensory Systems

4.2.4 Detection of Neuronal nAChR Subunit Proteins

4.2.4.1 Autonomic Nervous System

4.2.4.2 Sensory Systems

4.2.5 Detection of Neuronal nAChR Subunit Function

4.2.5.1 Cloned and Expressed Neuronal nAChRs

4.2.5.2 Native Receptors

4.2.6 Probing Function with Molecular Deletions: "Antisense" and Gene "Knock-Outs"

4.2.6.1 Autonomic Nervous System

4.2.6.2 Sensory Systems

4.3 Summary and Conclusions References

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