William L Gerald

Contents

9.1 Introduction 97

9.2 Clinical Issues 98

9.3 Technical Aspects of Gene Expression Analysis . 98

9.3.1 Transcript Profiling Methods 98

9.3.2 Data Analysis 100

9.3.3 The Impact of Tissue Heterogeneity on Gene Expression Analysis 100

9.4 Gene Expression Analysis of NB 100

9.4.1 The NB Transcriptome and Its Relationship to Neural Crest Development 100

9.4.2 Gene Expression Associated with Clinically Relevant Subtypes of NB . . 103

9.4.3 Molecular Pathology of MYCN Amplification 103

9.4.4 Distinct Molecular Features of NB Discovered Through Gene

Expression Analysis 105

9.5 Conclusion 106

References 106

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