Treatment Related Neurologic Complications

All multi-modality treatments for neuroblastoma can be complicated by a number of potential acute and chronic neurologic complications that may warrant immediate attention or long-term therapy; these include metabolic abnormalities (Antunes 2000), CNS changes and peripheral neuropathies (Reddy and Witek 2003; Yu et al. 1998; Cheung et al. 2001), infectious complications resulting in brain abscesses, meningitis, or encephalitis (Tasdemiroglu and Patchell 1997), or vascular events as a consequence of surgery, radiation therapy, or chemotherapy. The reader is referred to Chap. 18 on quality of life and late effects for further references.

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