Secreted Protein Acidic and Rich in Cysteine

Recently, another angiogenic inhibitor was isolated from Schwann cell-conditioned media, identified as secreted protein acidic and rich in cysteine (SPARC) (Chlenski et al. 2002). SPARC, also known as osteo-nectin, BM-40, and 43 K protein, is a highly conserved calcium-binding glycoprotein that plays a modulatory role in cell-matrix interactions and appears to contribute to vascular morphogenesis (Brekken and Sage 2001). SPARC is generally considered an antian-giogenic protein because it blocks VEGF- and FGF-2-induced proliferation of endothelial cells and can in

0 0

Post a comment