Octreotide Scanning

Many neuroendocrine tumors express somatostatin receptors, and the currently available In-111DTPA-pentetreotide (Octreoscan) detects the majority of NBs and pheochromocytomas; however, this compound appears to be inferior to MIBG for imaging these tumor types (Lauriero et al. 1995; Manil et al. 1996; Sautter-Bihl et al. 1994). Visualization of NBs in the abdomen and pelvis can be impaired by the marked normal hepatic, splenic, renal, and bowel uptake of this agent. In contrast to specificity of MIBG, Octreoscan images many types of neuroendocrine tumors, including carcinoids, islet cell tumors, pituitary adenomas, and medullary carcinoma of the thyroid, and non-neuroendocrine tumors, such as lymphomas and small cell carcinoma of the lung. Inflammatory infiltrates may also show uptake.

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