Neuron Specific Enolase

Neuron-specific enolase (NSE) is synthesized by neu-roblastoma cells and used as an immunohistoche-mical marker. Elevated serum levels have been reported in other neuroectodermal tumors such as Ewing's sarcoma, small cell lung cancer, and pheo-chromocytoma, as well as in acute lymphoblastic leukemia and non-Hodgkin's lymphoma (Hann and Bombardieri 2000). High levels at diagnosis were associated with poor outcome in several studies (cutoff levels 30-100 ng/ml) when corrected for stage (Zeltzer et al. 1983). Neuron-specific enolase is less specific for neuroblastoma than the catecholamine metabolites, but is more prognostic, and similarly valuable for monitoring recurrent disease (Simon et al. 2003).

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