How Neuroblastoma Escapes the Innate and Adaptive Immune Systems
Neuroblastoma employs a variety of tactics to evade the immune system (Table 14.2). It downregulates "immune-activating" while overexpressing "immune-inhibitory" receptors. By repressing the expression of class-I and class-II MHC (Lampson et al. 1983) as well as CD1d (Metelitsa et al. 2001), they interfere with both the afferent and efferent arms of adaptive immune response. In addition, NB cells can avoid immune recognition and destruction by releas
|
Modulated Ags |
Escape mechanism used by NB | |
|
Adaptive immunity T cells |
0MHC Class I 0Adhesion |
0ß2m, 0TAP1,0TAP2,0LMP2,0LMP7* 0ICAM2,0ICAM3,0LFA3 |
|
Innate immunity NK cells NKT cells Complement |
0Activation Tinhibition 0Activation Tinhibition ^Inhibition |
0MICA (cytoplasmic), 0MICB (cytoplasmic) (Raffaghello et al.2004) Soluble MICA (Doubrovina et al. 2003; Raffaghello et al. 2004) 0CD1d CD46, TCD59 |
Was this article helpful?
How To Bolster Your Immune System
All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.
Post a comment