History

In 1953 Robert E. Gross noted for neuroblastoma in infancy and childhood that "extensive and radical surgery has a definite place under certain circumstances and can lead to permanent cure" (Gross 1953). In 1955 C. Everett Koop described the positive effect of tumor de-bulking on outcome in a book he authored entitled, "Neuroblastoma in Childhood. Survival after Major Surgical Insult to the Tumor" (Koop et al. 1955). These were among the first publications in which a role for surgical resection in neu-roblastoma was reported. In 1968 Koop analyzed the impact of surgical interventions depending on whether the tumor was resectable, non-resectable, or

Table 11.4.1 High-risk neuroblastoma: review of the surgical literature

Positive effect of primary site resection Reference Number/stages

Little or no effect of surgical resection Reference Number/stages

Koop and Schnaufer (1975)

X/1-4

Kiely (1993)

80/3,4

Rosen et al.(1984)

136/1-4

Losty et al. (1993)

57/1-4

Le Tourneau et al. (1985)

130/1-4

Shorter et al.(1995)

79/1-4

Carlsen et al.(1986)

253/1-4

Kaneko et al.(1997)

14/4

Moss et al. (1987)

21/4

Kaneko et al.(1998)

36/1-4,4s

Matsumara et al.(1988)

320/4

Castel et al.(2002)

98/4

Haase et al.(1989)

58/3

Von Schweinitz et al. (2002)

878/4

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