Hiroyuki Shimada Inge M Ambros

Contents

8.1 Introduction 87

8.2 Historical Overview 88

8.3 Basic Morphology 88

8.3.1 Neuroblastoma

(Schwannian Stroma-poor) 89

8.3.2 Ganglioneuroblastoma, Intermixed (Schwannian Stroma-rich) 91

8.3.3 Ganglioneuroma

(Schwannian Stroma-dominant) 91

8.3.4 Ganglioneuroblastoma, Nodular (Composite, Schwannian Stroma-rich/ Stroma-dominant and Stroma-poor) 91

8.4 Prognostic Classification 92

8.5 Biological Relevance 92

8.5.1 Schwannian Development in Neuroblastic Tumors 92

8.5.2 Correlation of Histopathology with MYCN Amplification and trkA Expression 93

8.5.3 Composite Tumor 93

8.6 Conclusion 94

References 94

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