Expression of Proangiogenic Factors

The ability of neuroblastoma to produce proangio-genic factors was first described by Folkman in 1971, who isolated a "tumor angiogenic factor" from extracts of human neuroblastoma, Wilms' tumor, and hepatoblastoma (Folkman et al. 1971). The tumor extracts caused the formation of new blood vessels in the subcutaneous fascia of rats within 48 h. Since this time, expression of numerous proangiogenic factors, such as VEGF, PDGF, FGF, and angiopoietins, has been found in neuroblastoma.

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