Detection Methods for MRD

Numerous diverse techniques have been developed to detect and in some assays to quantify MRD in NB, because there may be an advantage to know the amount of residual tumor cells over simply establishing its presence. Optimal MRD assays must have superior sensitivity and specificity. The sensitivity of MRD detection methods is influenced by the source of tissue being analyzed and is limited by the number of cells available to be assayed. Moreover, the heterogeneity of tumor cell populations can result in some residual disease escaping detection.

0 0

Post a comment