Darrell JYamashiro Susan LCohn

Contents

16.1 Introduction 257

16.2 Vascularity in Neuroblastoma 258

16.3 Expression of Proangiogenic Factors 258

16.3.1 VEGF and VEGF Receptors 258

16.3.2 Matrix Metalloproteinases 259

16.4 Expression of Angiogenesis Inhibitors 260

16.4.1 Pigment Epithelium-Derived Factor 260

16.4.2 Secreted Protein Acidic and Rich in Cysteine 260

16.4.3 Thrombospondin-1 260

16.5 Regulation of Angiogenesis by MYCN 261

16.6 Preclinical Testing of Antiangiogenic Agents . . 261

16.6.1 VEGF Blockade 261

16.6.3 Endostatin 261

16.7 Conclusions 262

References 263

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