Imaging plays a critical role in evaluating the extent of disease at diagnosis and in assessing response to therapy. A variety of imaging modalities are available, and each can provide unique information. Radiation exposure, scanning protocols, and sedation times are significant factors that should be taken into account in determining which studies should be used. Minimizing radiation exposure is of paramount importance in the follow-up of neonates and young infants with favorable biology NB. At the present time, several different imaging studies are needed to optimally evaluate the primary tumor, and the presence and location of metastatic disease. New imaging modalities may improve our ability to evaluate NB with less risk of radiation exposure.

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