Clinical Application of MAb 14421 Naked MAb

Among the ganglioside antigens, GD2 is particularly relevant for the treatment of NB. Neuroblastoma cells express GD2 at high density, with relatively little heterogeneity within tumors or among patients (Schulz et al. 1984; Kramer et al. 1998). GD2 is not lost from the cell surface when bound to antibodies. In normal serum, GD2 is found in low concentrations typically bound to lipoproteins. This may explain why circu-

Table 14.3. Use of MAb for clinical diagnosis and therapy of neuroblastoma3

Radiolabeled antibody for imaging

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