Carol JThiele C Patrick Reynolds

Contents

15.1 Introduction 243

15.1.1 Neural Crest Development 243

15.1.2 NB as a Neural Crest Derivative 244

15.1.3 NB and Adrenal Medullary Development . 244

15.1.4 Neural Crest Gene Expression During Development 245

15.1.5 MYCN in Neural Crest Development 245

15.2 Neurotrophins in Neural Crest Development . . 245

15.2.1 TrkA and NB 246

15.3 Differentiation 247

15.3.1 Retinoids 247

15.3.2 Retinoic Acid Receptors 248

15.4 13-cis-Retinoic Acid 249

15.4.1 High-Dose, Pulse, 13-cis-RA 250

15.4.2 13-cis-RA vs All Trans-Retinoic Acid 250

15.4.3 Post-Consolidation 13-cis-RA Therapy for High-Risk NB 250

15.5 Fenretinide 253

15.6 Conclusions 254

References 254

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