Adoptive Therapy Using Allogeneic Lymphocytes

Infusion of allogeneic immune cells, although effective in certain hematopoietic malignancies, has not been tested extensively for NB. In contrast to the advantage of allogeneic BMT over autologous BMT for several hematopoietic malignancies, several studies have shown equivalent or inferior progressionfree survival probabilities in NB patients receiving allografts when compared with those receiving auto-grafts (Philip et al. 1997; Matthay et al. 1994; Evans et al. 1994). In addition, patients receiving the allo-geneic transplants appeared to have more peri-transplant toxicities. With recent improvements in supportive care and GVH prophylaxis, further clinical testing of graft-vs-tumor effect is being considered for NB.

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