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15 days

Patient Number

Figure 5. Effect of radiodetoxified endotoxin (RD-I.PS: TOLERIN) on the number of Icucocytes in CYSPLATIN treated patients bearing testis tumours.

Patient Number

Figure 5. Effect of radiodetoxified endotoxin (RD-I.PS: TOLERIN) on the number of Icucocytes in CYSPLATIN treated patients bearing testis tumours.

We also treated five individuals suffering from immunodeficiency in addition to the usual treatment regimes given to these patients. Allhough TOLERIN increased Cl)4 number in patients with full-blown AIDS, no clinical improvement was obvious in the treated individuals. This observation correlates with our in vitro studies performed earlier. However, in one patient aged 28 years there was a significant clinical improvement after TOLERIN treatment. This patient suffered from severe meningitis and encephalitis qf unknown origin, Candida sepsis and mixed bacterial infections. The CD4+ and CD8+ T-cell count was 250 and 261, respectively. TOLERIN was given two times at 280 |ig subeulaneously (the second treatment was given 60 days after the first), and it increased significantly the CD4+ and CD8+ lymphocyte count. There was improvement already after the first treatment and after the second treatment the CD4+/ CD8+ ratio was 1.05. One year later the CD4+/CD8+ ratio increased to 2.0, which is slightly over normal. Bone marrow function was normalized by this treatment [86].

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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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