Cytokine Activity

Since about 1986, there has been a growing literature focusing on cytokines in invertebrates [37,38] (Tables IV and V). Studies have yielded functional evidence but prevailing controversy concerns molecular structure. Several invertebrate species have been examined including arthropods, annelids, mollusks and echinoderms. However, the bulk of the more credible information has been derived from the tunicates. Within the last 10 years, this evidence is even more compelling especially when we view the noteworthy results recently published concerning the draft genome of Ciona intestinalis [11], Thus the earlier functional evidence is corroborated by genetic data.

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