Conclusions

As we further our understanding of host defence regulation at the organismal level, we can appreciate the complexity of pathways within the innate immune system and the central position held by antimicrobial peptides. Unravelling their molecular structure has provided investigators with novel insights into mechanisms for regulating their biosynthesis, processing and release. With many surprises still to come, it is likely that future generations of epithelial biologists will view the innate and adaptive immune systems as a continuum, with antimicrobial peptides playing key roles both as regulatory and effector elements.

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