Conclusions

Clearly the mediators of the innate immune response are essential for normal tissue remodelling typified in the continuous homeostasis of the epidermis, wound healing and the cyclical changes associated with mammalian reproduction. Embryonic development depends upon the components of the innate immune system and the evidence is extended by the discovery that Toll receptors which are essential for fly development are major signalling receptors of the innate immune response. The evidence supports physiologic roles beyond defence for the natural immune system. The questions regarding the evolutionary pressure responsible for the development of the innate immune system can not be denied and this is completely entangled in the issue regarding self-nonself discrimination, suggesting a self-centred organizational strategy for survival.

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