Clm

Mollusca

Planorbarius corneas Vivíparas ater Vivíparas contectus Lymnaea stagnalis Mytilus galloprovincialis

Insecta

Calliphora vomitoria Galleria mellonella Estigmene acraea Lymantria dispar

Nematoda

Caenorhabditis elegans

Annelida

Eisenia foetida

Tunicata

Botryllus schlosserii Ciona intestinalis

TNF-a, PDGF-AB, TGF-ßl IL-la, TNF-a IL-la, TNF-a PDGF-AB, TGF-ßl

Table V Effects of mammalian cytokines on different invertebrate functions (modified from Ottaviani).

Cytokine Function

PDGF-AB, TGF-|3l Wound repair; apoptosis

PDGF-AB, TGF-Pl, IL-8 Cell motility

PDGF-AB, TGF-pi, IL-la, TNF-a, IL-8 Cell migration

IL-la, TNF-a, IL-2 Phagocytosis; NOS production

IL-2 NK-like activity

PDGF-AB, TGF-Pl, IL-la,p, IL-2, IL-6, TNF-a,P Stress response ated coelomocyte locomotion.

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