Bile Deficiency And Radiationinduced Intestinalsyndrome

It is clear that the intestinal syndrome associated with radiation disease is caused by bacterial endotoxins. Because bile acids are capable of endotoxin detoxification and bile deficiency permits the absorption of endotoxins into the bloodstream ('translocation'), one may ask the question whether or not bile deficiency would play a role in radiation disease. For this reason we studied in rats the effect of experimental bile deficiency on the development of radiation-induced intestinal syndrome. It was observed that the rats having bile fistulas died of radiation disease within five days, whereas the control irradiated and sham-operated irradiated animals survived for 11 days. Apparently bile deficiency accelerated the development of endotoxaemia in this model [44J.

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