Abstract

The term natural resistance refers to the capacity of living organisms to withstand injury caused by physical, chemical and biological agents that may be present in the external or internal environment. This protection is mediated by the natural, or innate, immune system, a multi-factorial and polyspecific defence system. Evolutionarily preserved germ-line receptors mediate the activation of natural immune cells that recognize genetically preserved, cross-reactive homologous epitopes (homotopes) in micro-organisms, cancer cells, virus-infected cells and distressed cells. In general, protection is based on balancing the defence mechanisms of the organism with the damaging effects of harmful agents. This defence comprises epithelial, secretory and endogenous mechanisms in addition to the cellular and humoural components of the natural immune system. In recent years, a continuing surge of exploration and discussion has helped to crystallize our appreciation of the molecular mechanisms of this innate system, their basis in evolution, physiological, pathological and behavioural significance and their regulation, in particular their intimate connection with the neuroendocrine system. In higher animals natural immune mechanisms are boosted profoundly during acute febrile illness leading to the release of pro-inflammatory cytokines, IL-1, TNF-alpha and IL-6, which in turn activate the neuroimmune regulatory network. The HPA axis and the sympathetic nervous system is activated and catabolism prevails. IL-6, glucocorticoids and cathecolamines induce the production of acute phase proteins permitting a rapid activation of phagocytic and cytotoxic mechanisms under the command of natural antibodies and other recognition molecules (e.g. C-reactive protein, endotoxin binding and man-nose binding proteins). The acute phase response is a highly co-ordinated emergency defence reaction, which relies on the interaction of neuroendocrine, immune and metabolic mechanisms in the interest of maximum host defence during emergency situations, such as sepsis. In most cases febrile illness leads to healing and recovery, which attests to the effectiveness of the natural immune system and excites the desire for the benefits which should accrue from mastering the manipulation of this system.

Natural Treatments For Psoriasis

Natural Treatments For Psoriasis

Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.

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