Abstract

The natural immune response is a pre-programmed, non specific first line of defence that is primarily responsible for eliminating or containing pathogens at the site of entrance into the host. This evolutionary conserved function was primarily described in cells of the immune system, but it is now known to exist in various tissues, where its activation plays a significant role in host defence, autoimmunity, inflammatory disease and pathogenesis of sepsis-induced multiorgan dysfunction. It is also emerging in the last years as a possible role for natural immunity in the aging process, and its role in tumour immunosurveillance is undergoing a great revival. This Chapter will briefly summarise the importance of natural immunity in all of these phenomena.

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