The immunostimulating and antitumor properties of Ganoderma and shiitake mushrooms have been dis cussed in at least five reviews
In addition to these, two in-vitro studies have reported they can increase cy-tokine production, stimulate immune cells, and induce differentiation of cancer cells via cytokine activity.63,64 Nine studies have reported antitumor effects in ani-
mals. - A large number of additional animal and human cancer studies have been published on the purified polysaccharide lentinan, isolated from shiitake.
Based on the extensive anticancer data of lentinan, it would seem reasonable that crude shiitake extracts could also produce an immunostimulating effect and be useful in cancer treatment. The few studies on crude shiitake and Ganoderma extracts suggest both may indeed be helpful.
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