Axonal/neuronal loss is an important feature of MS pathology, and it is likely to represent one of the main factors responsible for the accumulation of irreversible disability. The application of modern MR techniques to the in vivo study of MS is providing important insights into the patho-physiology of the disease, and it is establishing new markers to understand and monitor MS evolution. None of the quantitative MR-based techniques taken in isolation is likely to be able to provide a complete picture of the complexity of the MS process, and this should call for the definition of aggregates of MR measurements thought to reflect different aspects of MS pathology. This approach is likely to enhance our ability to monitor the disease and to improve the correlation between MRI metrics and disability.

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