Pharmacological Manipulation of the Axonal Injury Cascade

Figure 2 Molecular cascade leading to elevations of intracellular Ca2+, which can result in axonal degeneration. Depolarization, anoxia, and nitric oxide (NO) can each trigger downstream events causing the intra-axonal influx of Na+ and the reverse function of the Na+/Ca2+ exchanger, leading to axonal degeneration.

Figure 2 Molecular cascade leading to elevations of intracellular Ca2+, which can result in axonal degeneration. Depolarization, anoxia, and nitric oxide (NO) can each trigger downstream events causing the intra-axonal influx of Na+ and the reverse function of the Na+/Ca2+ exchanger, leading to axonal degeneration.

This section reviews the effect of drugs and other interventions that can modulate or interfere with the axonal calcium influx cascade.

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