Akiyama, Y., Radtke, C., Honmou, O., and Kocsis, J. D. (2002a). Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia 39, 229-236. Akiyama, Y., Radtke, C., and Kocsis, J. D. (2002b). Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells. J. Neurosci. 22, 6623-6630. Akiyama, Y., Lankford, K. L., Radtke, C., Greer, C. A., and Kocsis, J. D. (2004). Remyelination of spinal cord axons by olfactory ensheathing cells and Schwann cells derived from a transgenic rat expressing alkaline phosphatase marker gene. Neuron Glia Biol. 1, 1-9. Alvarez-Dolado, M., Pardal, R., Garcia-Verdugo, J. M., Fike, J. R., Lee, H. O., Pfeffer, K., Lois, C., Morrison, S. J., and Alvarez-Buylla, A. (2003). Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425, 968-973.

Au, E., and Roskams, A. J. (2003). Olfactory ensheathing cells of the lamina propria in vivo and in vitro. Glia 41, 224—236.

Azizi, S. A., Stokes, D., Augelli, B. J., DiGirolamo, C., and Prockop, D. J. (1998). Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats: Similarities to astrocyte grafts. Proc. Natl. Acad. Sci. U. S. A. 95, 3908-3913

Barnett, S. C., Alexander, C. L., Iwashita, Y., Gilson, J. M., Crowther, J., Clark, L., Dunn, L. T., Papanastassiou, V, Kennedy, P. G., and Franklin, R. J. (2000). Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons. Brain 123, 1581-1588.

Baron-Van Evercooren, A., Gansmuller, A., Duhamel, E., Pascal, F., and Gumpel, M. (1992). Repair of a myelin lesion by Schwann cells transplanted in the adult mouse spinal cord. J. Neuroimmunol. 40, 235-242.

Blakemore, W. F. (1977). Remyelination of CNS axons by Schwann cells transplanted from the sciatic nerve. Nature 266, 88-69.

Blakemore, W. F., and Crang, A. J. (1985). The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system. J. Neurol. Sci. 70, 207-223.

Blakemore, W. F., Crang, A. J., et al. (1986). The interaction of Schwann cells with CNS axons in regions containing normal astrocytes. Acta Neuropathol. 71(3-4), 295-300.

Blann, A., Kumar, P., Krupinski, J., McCollum, C., Beevers, D. G., and Lip, G. Y. (1999). Soluble intercelluar adhesion molecule-1, E-selectin, vascular cell adhesion molecule-1 and von Willebrand factor in stroke. Blood Coagul. Fibrinolysis 10, 277-284.

Blight, A. R., and Young, W. (1989). Central axons in injured cat spinal cord recover electrophysiological function following remyelination by Schwann cells. J. Neurol. Sci. 91, 15-34.

Boyd, J. G., Lee, J., Skihar, V, Doucette, R., and Kawaja, M. D. (2004). LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cord. Proc. Natl. Acad. Sci. U. S. A. 101, 2162-2166.

Brook, G. A., Plate, D., Franzen, R., Martin, D., Moonen, G., Schoenen, J., Schmitt, A. B., Noth, J., and Nacimiento, W. (1998). Spontaneous longitudinally orientated axonal regeneration is associated with the Schwann cell framework within the lesion site following spinal cord compression injury of the rat. J. Neurosci. Res. 53, 51-65.

Brustle, O., Jones, K. N., Learish, R. D., Karram, K., Choudhary, K., Wiestler, O. D., Duncan, I. D., and McKay, R. D. (1999). Embryonic stem cell-derived glial precursors: A source of myelinating transplants. Science 285, 754-756.

Cai, D., Qiu, J., Cao, Z., McAtee, M., Bregman, B. S., and Filbin, M. T. (2001) Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J. Neurosci. 21, 4731-4739.

Cajal, S. R. Y. (1928). "Degeneration and Regeneration in the Nervous System." Oxford University Press, London.

Castro, R. F., Jackson, K. A., Goodell, M. A., Robertson, C. S., Liu, H., and Shine, H. D. (2002). Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science 297, 1299.

Chen, J., Sanberg, P. R., Li, Y., Wang, L., Lu, M., Willing, A. E., Sanchez-Ramos, J., and Chopp, M. (2001). Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 32, 2682-2688.

Chuah, M. I., and West, A. K. (2002). Cellular and molecular biology of ensheathing cells. Microsc. Res. Tech. 58, 216-227.

Devon, R., and Doucette, R. (1992). Olfactory ensheathing cells myelinate dorsal root ganglion neurites. Brain Res. 589, 175-179.

Doucette, R. (1984). The glial cells in the nerve fiber layer of the rat olfactory bulb. Anat. Rec. 210(2), 385-391.

Doucette, R. (1991). PNS-CNS transitional zone of the first cranial nerve. J. Comp. Neurol. 312, 451-466.

Eglitis, M. A., Dawson, D., Park, K. W., and Mouradian, M. M. (1999). Targeting of marrow-derived astrocytes to the ischemic brain. Neuroreport 10, 1289-1292.

Felts, P. A., and Smith, K. J. (1992). Conduction properties of central nerve fibers remyelinated by Schwann cells. Brain Res. 574, 178-192.

Ferrari, G., Cusella-De Angelis, G., Coletta, M., Paolucci, E., Stornaiuolo, A., Cossu, G., and Mavilio, F. (1998). Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279, 1528-1530.

Franklin, R. J., Gilson, J. M., Franceschini, I. A., and Barnett, S. C. (1996). Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS. Glia 17, 217-224.

Franklin, R. J., and Barnett, S. C. (1997). Do olfactory glia have advantages over Schwann cells for CNS repair? J. Neurosci. Res. 50(5), 665-672.

Franklin, R. J., and Barnett, S. C. (2000). Olfactory ensheathing cells and CNS regeneration: The sweet smell of success? Neuron 28(1), 15-18.

Friedenstein, A. J. (1976). Precursor cells of mechanocytes. Int. Rev. Cytol. 47, 327-359.

Gage, F. H., Ray, J., and Fisher, L. J. (1995). Isolation, characterization, and use of stem cells from the CNS. Annu. Rev. Neurosci. 18, 159-192

Gledhill, R. F., Harrison, B. M., and McDonald, W. I. (1973). Pattern of remyelination in the CNS. Nature 244, 443-444.

Graziadei, P. P., Levine, R. R., and Graziadei, G. A. (1978). Regeneration of olfactory axons and synapse formation in the forebrain after bulbec-tomy in neonatal mice. Proc. Natl. Acad. Sci. U. S. A. 75, 5230-5234.

Guenard, V, Gwynn, L. A., et al. (1994). Astrocytes inhibit Schwann cell proliferation and myelination of dorsal root ganglion neurons in vitro. J. Neurosci. 14(5 Pt 2), 2980-2992.

Hammang, J. P., Archer, D. R., and Duncan, I. D. (1997). Myelination following transplantation of EGF-responsive neural stem cells into a myelin-deficient environment. Exp. Neurol. 147, 84-95.

Han, S. S., Kang, D. Y., Mujtaba, T., Rao, M. S., and Fischer, I. (2002). Grafted lineage-restricted precursors differentiate exclusively into neurons in the adult spinal cord. Exp. Neurol, 177, 360-375.

Haraldsen, G., Kvale, D., Lien, B., Farstad, I. N., and Brandtzaeg, P. (1996). Cytokine-regulated expression of E-selectin, intercellular adhesion mol-ecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J. Immunol. 156, 2558-2565.

Hofstetter, C. P., Schwarz, E. J., Hess, D., Widenfalk, J., El Manira, A., Prockop, D. J., and Olson, L. (2002). Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc. Natl. Acad. Sci. U. S. A. 99, 2199-2204.

Honmou, O., Felts, P. A., Waxman, S. G., and Kocsis, J. D. (1996). Restoration of normal conduction properties in demyelinated spinal cord axons in the adult rat by transplantation of exogenous Schwann cells. J. Neurosci. 16, 3199-3208.

Huang, H., Chen, L., Wang, H., Xiu, B., Wang, R., Zhang, J., Zhang, F., Gu, Z., Li, Y., Song, Y., Hao, W., Pang, S., and Sun. J. (2003). Influence of patients' age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury. Chin. Med. J. (Engl.) 116, 1488-1491.

Ide, C. (1996) Peripheral nerve regeneration. Neurosci. Res. 25, 101-121.

Iihoshi, S., Honmou, O., Houkin, K., Kazuo, H., and Kocsis, J. D. (2004). A therapeutic window for an intravenous administration of autologous bone marrow after cerebral ischemia in adult rats. Brain Res. 1007, 1-9.

Imaizumi, T., Lankford, K. L., Waxman, S. G., Greer, C. A., and Kocsis, J. D. (1998). Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord. J. Neurosci. 18, 6176-6185.

Imaizumi, T., Lankford, K. L., and Kocsis, J. D. (2000a). Transplantation of olfactory ensheathing cells or Schwann cells restores rapid and secure conduction across the transected spinal cord. Brain Res. 854, 70-78.

Imaizumi, T., Lankford, K. L., Burton, W. V, Fodor, W. L., and Kocsis, J. D. (2000b). Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord. Nat Biotechnol 18, 949-953.

Inoue M, Honmou O, Oka S, Houkin K, Hashi K, Kocsis JD. (2003) Comparative analysis of remyelinating potential of focal and intravenous administration of autologous bone marrow cells into the rat demyelinated spinal cord. Glia 44, 111-118.

Kato, T., Honmou, O., Uede, T., Hashi, K., and Kocsis, J. D. (2000). Transplantation of human olfactory ensheathing cells elicits remyelina-tion of demyelinated rat spinal cord. Glia 30, 209-218.

Keyvan-Fouladi, N., Raisman, G., and Li, Y. (2003). Functional repair of the corticospinal tract by delayed transplantation of olfactory ensheath-ing cells in adult rats. J. Neurosci. 23, 9428-9434.

Kim, J. S. (1996). Cytokines and adhesion molecules in stroke and related diseases. J. Neurol. Sci. 137, 69-78.

Kisseberth, W. C., Brettingen, N. T., Lohse, J. K., and Sandgren, E. P. (1999). Ubiquitous expression of marker transgenes in mice and rats. Dev. Biol. 214, 128-138.

Kobune, M., Kawano, Y., Ito, Y., Chiba, H., Nakamura, K., Tsuda, H., Sasaki, K., Dehari, H., Uchida, H., Honmou, O., Takahashi, S., Bizen, A., Takimoto, R., Matsunaga, T., Kato, J., Kato, K., Houkin, K., Niitsu, Y., and Hamada, H. (2003). Telomerized human multipotent mesenchy-mal cells can differentiate into hematopoietic and cobblestone area-supporting cells. Exp. Hematol. 31(8), 715-722.

Kohama, I., Lankford, K. L., Preiningerova, J., White, F. A., Vollmer, T. L., and Kocsis, J. D. (2001). Transplantation of cryopreserved adult human Schwann cells enhances axonal conduction in demyelinated spinal cord. J. Neurosci. 21, 944-950.

Lakatos, A., Franklin, R. J., et al. (2000). Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes. Glia 32(3), 214-225.

Lakatos, A., Smith, P. M., Barnett, S. C., and Franklin, R. J. (2003). Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells. Brain 126, 598-609.

Lankford, K. L., Imaizumi, T., Honmou, O., and Kocsis, J. D. (2002). A quantitative morphometric analysis of rat spinal cord remyelination following transplantation of allogenic Schwann cells. J. Comp. Neurol. 443, 259-274.

Li, Y., Field, P. M., and Raisman, G. (1997). Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells. Science 277, 2000-2002.

Li, Y., Field, P. M., and Raisman, G. (1998). Regeneration of adult rat cor-ticospinal axons induced by transplanted olfactory ensheathing cells. J. Neurosci. 18, 10514-10524.

Li, Y., Chen, J., Chen, X. G., Wang, L., Gautam, S. C., Xu, Y. X., Katakowski, M., Zhang, L. J., Lu, M., Janakiraman, N., and Chopp, M. (2002). Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery. Neurology 59, 514—523

Lu, J., Feron, F., Mackay-Sim, A., and Waite, P. M. (2002). Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain 125, 14-21.

Majumdar, M. K., Thiede, M. A., Mosca, J. D., Moorman, M., and Gerson, S. L. (1998). Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J. Cell Physiol. 176, 57-66.

Mujtaba, T., Han, S. S., Fischer, I., Sandgren, E., and Rao, M. S. (2002). Stable expression of the alkaline phosphatase marker gene by neural cells in culture and after transplantation into the CNS using cells derived from a transgenic rat. Exp. Neurol. 174, 48-57.

Namiki, J., Kojima, A., and Tator, C. H. (2000). Effect of brain-derived neu-rotrophic factor, nerve growth factor, and neurotrophin-3 on functional recovery and regeneration after spinal cord injury in adult rats. J. Neurotrauma 17, 1219-1231.

Pearse, D. D., Pereira, F. C., Marcillo, A. E., Bates, M. L., Berrocal, Y. A., Filbin, M. T., and Bunge, M. B. (2004). cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat. Med. 10, 610-616.

Pixley, S. K. (1992). The olfactory nerve contains two populations of glia, identified both in vivo and in vitro. Glia 5, 269-284.

Plant, G. W., Currier, P. F., Cuervo, E. P., Bates, M. L., Pressman, Y., Bunge, M. B., and Wood, P. M. (2002). Purified adult ensheathing glia fail to myelinate axons under culture conditions that enable Schwann cells to form myelin. J. Neurosci. 22, 6083-6091.

Plant, G. W., Christensen, C. L., Oudega, M., and Bunge, M. B. (2003). Delayed transplantation of olfactory ensheathing glia promotes sparing/regeneration of supraspinal axons in the contused adult rat spinal cord. J. Neurotrauma 20, 1-16.

Prineas, J. W., and Connell, F. (1979). Remyelination in multiple sclerosis. Ann. Neurol. 5, 22-31.

Quesenberry, P. J., and Becker, P. S. (1998). Stem cell homing: Rolling, crawling, and nesting. Proc. Natl. Acad. Sci. U. S. A. 95, 15155-15157.

Radtke, C., Akiyama, Y., Brokaw, J., Lankford, K. L., Wewetzer, K., Fodor, W. L., and Kocsis, J. D. (2004). Remyelination of the nonhuman primate spinal cord by transplantation of H-transferase transgenic adult pig olfactory ensheathing cells. FASEB J. 18, 335-337. Full text: FASEB Journal Express Article 10.1096/fj.03-021 fje 2003.

Ramer, L. M., Au, E., Richter, M. W., Liu, J., Tetzlaff, W., and Roskams, A. J. (2004) Peripheral olfactory ensheathing cells reduce scar and cavity formation and promote regeneration after spinal cord injury. J. Comp. Neurol. 473, 1-15.

Ramon-Cueto, A., and Avila, J. (1998). Olfactory ensheathing glia: properties and function. Brain Res. Bull. 46, 175-187.

Ramon-Cueto, A., Plant, G. W., Avila, J., and Bunge, M. B. (1998). Longdistance axonal regeneration in the transected adult rat spinal cord is promoted by olfactory ensheathing glia transplants. J. Neurosci. 18, 3803-3815.

Ramon-Cueto, A., Cordero, M. I., Santos-Benito, F. F., and Avila, J. (2000). Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron 25, 425-435.

Ramon-Cueto, A., and Valverde, F. (1995). Olfactory bulb ensheathing glia: A unique cell type with axonal growth-promoting properties. Glia 14(3), 163-173.

Sasaki, M., Honmou, O., Akiyama, Y., Uede, T., Hashi, K., and Kocsis, J. D. (2001). Transplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axons. Glia 35, 26-34.

Sasaki, M., Lankford, K. L., Zemedkun, M., and Kocsis, J. D. (2004). Olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelin. J. 24, 8485-8493. Neurosci.

Senior, K. (2002). Olfactory ensheathing cells to be used in spinal-cord repair trial. Lancet Neurology 1, 269.

Snyder, E. Y., Yoon, C., Flax, J. D., and Macklis, J. D. (1997). Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex. Proc. Natl. Acad. Sci. U. S. A. 94, 11663-11668.

Takami, T., Oudega, M., Bates, M. L., Wood, P. M., Kleitman, N., and Bunge, M. B. (2002). Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord. J. Neurosci. 22, 6670-6681.

Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mort, S., and B., L. (1998). Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 338, 278-285.

Verdu, E., Garcia-Alias, G., et al. (2001). Effects of ensheathing cells transplanted into photochemically damaged spinal cord. Neuroreport 12(11), 2303-2309.

Vermeulen, M., Le Pesteur, F., Gagnerault, M. C., Mary, J. Y., Sainteny, F., and Lepault, F. (1998). Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells. Blood 92, 894-900.

Woodbury, D., Schwarz, E. J., Prockop, D. J., and Black, I. B. (2000). Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61, 364-370.

Woodhall, E., West, A. K., and Chuah, M. I. (2001). Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neu rotrophic factor, glia cell line-derived neurotrophic factor and their receptors. Brain Res. Mol. Brain Res. 88, 203-213. Zhang, R. L., Chopp, M., Zaloga, C., Zhang, Z. G., Jiang, N., Gautam, S. C., Tang, W. X., Tsang, W., Anderson, D. C., and Manning, A. M. (1995). The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat. Brain Res. 682, 182-188.

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