Multiple Sclerosis

Molecular Axon Components

Wallerian Degeneration Axons

Although a number of molecules, or classes of molecules, secreted by activated immune cells have been implicated in axon injury in MS, the early events leading to transection of the axon have not been studied in any depth. The appearance of the axon end-bulb already indicates that axon injury has proceeded to an irreversible state. The sealing of the ends of an injured axon involves calcium-dependent processes including activation of calpain and phospholipase A2 (Howard et al., 1999 Geddis and...