Viruses

Viruses are known leukemogens for hematopoietic cancers in several animal species.145 One definitive association that has been established in humans is viral infection with HTLV-1 and the development of a very rare type of leukemia (T-cel! ALL).146 The virus is endemic in parts of the Carribean, Japan, and Central Africa, with a reported seroprevalence of 30 percent or higher.147 The lifetime risk of an HTLV-1-infected individual developing T-cell ALL is estimated to be between 3 and 5 percent.148 Moreover, earlier infection with the virus appears to be predictive of risk. Other viruses that have been explored with respect to acute leukemia include bovine leukemia, feline leukemia, Epstein-Barr, and hepatitis B, with largely negative results.108

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