The Relationship Between Genetic Abnormalities And Immunoglobulin Vh Gene Mutations

Two recent studies have shown that the mutational status of the variable region of the immunoglobulin gene is a powerful prognostic indicator in CLL. Patients with unmutated VH genes have a significantly poorer survival than those with VH gene mutations.82,83 Preliminary data from our own group and from Germany in over 400 patients with CLL show a significant association between unmutated VH genes and deletions of 11q23 and 17p, whereas cases with mutated VH genes are associated with a normal karyotype or deletions of 13q14.84,85

For patients with either trisomy 12 or deletion of 13q14, survival is significantly prolonged when there is mutation of VH genes than when they remain unmutated. Our own data demonstrated a median survival of 95 months for patients with tri-somy 12 and unmutated VH genes, whereas the median survival

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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