Structural Abnormalities Involving Chromosome

Several groups have observed a strong correlation between structural rearrangements of chromosome 16 and acute myelomono-cytic leukemia with eosinophilia (M4Eo).119-121 Deletions— del(16)(q22)—and inversions—inv(16)(p13;q22)—involving the long arm of the chromosome appear to produce the same clinical features. The eosinophils account for 5 percent or more of the nonerythroid cells. They are reactive to CAE and PAS, contrary to normal eosinophils. In addition to M4Eo structural abnormalities involving chromosome 16 have been demonstrated in cases of M2, M5, and in blast crisis of CML.121 Patients with chromosome 16 abnormalities tend to respond to chemotherapy better, experience relatively long remissions, and have a better prognosis.71,107,121,122

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