In PV, Epo levels are characteristically reduced and remain below the lower level of the normal range in the majority of patients following the normalization of their Hb and Hct. In secondary erythrocytosis due to tissue hypoxemia Epo levels are usually raised. In the rare recessive or dominant erythrocytoses due to an autonomous high Epo production99-102 different Epo patterns are seen. Some are associated with raised Epo levels irrespective of the Hct, whereas some only have a raised Epo level following Hb reduction to within the normal range.

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