Richard M Stone and Arthur T Skarin

The chronic leukemias, chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL), are hematopoietic malignancies with a relatively indolent clinical course. However, these diseases represent examples of different pathophysiological entities: CML is a myeloproliferative disorder (MPD) whereas CLL falls in the spectrum of chronic lymphoproliferative disease with circulating neoplastic cells. This chapter emphasizes the pathological findings in CML, CLL, and related entities. Indolent lymphoproliferative neoplasms in which a leukemic phase is infrequent are covered in Sections IV (non-Hodgkin's lymphoma) and III (multiple myeloma). Molecular biological, immunobiological, and clinical aspects of the chronic leukemias are discussed in Chapters 4 through 9.

BONE MARROW STEM CELL DISORDERS: MYELOPROLIFERATIVE DISORDERS AND MYELODYSPLASTIC SYNDROMES

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