Refractory Cytopenia With Multilineage Dysplasia RCMD

In 1996 Rosati et al.170 reviewed 60 patients for whom the original diagnosis was RA, RARS, unclassifiable, or RAEB, and identified 18 cases characterized by multilineage dysplasia, but with an insufficient number of bone marrow blast cells to meet the FAB criteria for RAEB. This subset of MDS, named refractory cytopenia with multilineage dysplasia (RCMD), had a short survival time (24 months), more similar to that of RAEB (18 months) than RA/RARS (107 months). After this publication, several studies confirmed the previously reported findings.171,172 Therefore, it is incorporated as a new subgroup of MDS classification.11

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