Pregnancy and Fertility

The natural physiological changes in pregnancy, such as hemodilution and a mild thrombocytopenia may help to ameliorate the thrombotic diathesis that is present in patients with PV.123 Pregnancy itself, however, is a physiological hypercoagu-lable state, with an increase in procoagulant clotting factors (e.g. factor VII, factor VIII, and fibrinogen) and a decrease in natural anticoagulants (e.g., free protein S), occurring from about the third month of pregnancy.124

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