The fourth edition of Neoplastic Diseases of the Blood is long overdue, as evidenced by the tremendous progress made in our understanding of the nature of hematologic malignancies and their treatment since the third edition appeared in 1995. The fourth edition is current and up to date, draws heavily on recent references, and is designed, as were the previous editions, to be a readable encyclopedic resource for established hematologists and oncologists as well as for Fellows in those disciplines. Six new chapters are included in this edition, and all other chapters have been extensively revised and updated. The new chapters concern the epidemiology of chronic leukemias, molecular biology and cytogenetics of chronic myeloid leukemia, myelodysplastic syndromes, cytokines and signal transduction in multiple myeloma, umbilical cord stem cell transplantation, and HLA typing in hematopoietic cell transplantation. Some 112 authors from 4 continents, more than 50 new to this edition, have contributed their expertise to this work. This edition is divided into the same five sections found in earlier editions, each the primary responsibility of an editor: Chronic Leukemias and Related Disorders (John M. Goldman), Acute

Leukemia (Peter H. Wiernik), Myeloma and Related Disorders (Robert A. Kyle), Lymphoma (Peter H. Wiernik), and Supportive Care (Janice P. Dutcher). Dr. Goldman is a new editor for this edition, and those of us who have served as editors previously are delighted to have him join us.

Our sincere hope is that patients with hematologic malignancies will benefit directly from this new edition. That hope is what drives us to take on and complete the huge task that is the creation of this book.

We wish to thank the publisher, Cambridge University Press, for assisting us in every way possible through all phases of the development of the book. Special thanks to Heidi Steinmetz Lovette, Editor, Medicine, and Dr. Richard Barling, Director, Medical and Professional Publishing, for guidance and support. Both were instrumental in bringing this project to completion.

Peter H. Wiernik, MD John M. Goldman, MD Janice P. Dutcher, MD Robert A. Kyle, MD

Peter H. Wiernik
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