Phlebotomy reduces the hematocrit by the direct removal of blood and, by inducing iatrogenic iron deficiency, controls ery-throcyte overproduction without affecting platelet and white cell counts. The PVSG-01 trial was performed over 20 years ago and randomized 431 patients to phlebotomy or myelosuppres-

Table 9-5. Summary of the Major Trials Conducted in Polycythemia Vera.

Study Patients and Follow-Up Treatment and Main Results

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