PGlycoprotein Expression in Acute Lymphocytic Leukemia

Contrary to the association of CD34 with functionally active P-glycoprotein, (Pgp), the product of the MDR-1 gene, in AML,139,357-359 there exists no apparent correlation between

MDR-1 gene transcription and CD34 in adult ALL360 (Paietta E, unpublished observation). The frequency of functionally active Pgp in ALL appears low.359,360 The clinical significance of MDR in ALL is unclear, based on small studies and equivocal tech-nologies.142,360-364 P-Glycoprotein in ALL may be associated with other poor prognostic features, such as high white blood cell count, FAB L3, and a mature B-cell phenotype.362

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